Pantover

Pantoprazole USP 20 mg tab, Pantoprazole USP 40 mg Inj

Pantover 20: Each enteric coated tablet contains Pantoprazole Sodium Sesquihydrate USP equivalent to Pantoprazole 20 mg.
Pantover 40 IV Injection: Each vial contains sterile Pantoprazole Sodium Sesquihydrate BP equivalent to Pantoprazole 40 mg.

Pantover tablets are used for:
• treating mild forms of oesophageal disease caused by reflux of acid from the stomach (with or without mild inflammation of the oesophagus) and the associated symptoms (e.g. heartburn, acid regurgitation, pain on swallowing).
• long-term management of reflux oesophagitis (inflammation of the oesophagus accompanied by the regurgitation of stomach acid) and preventing its return.
• preventing duodenal and stomach ulcers caused by non-steroidal anti-inflammatory drugs (NSAIDs, for example, ibuprofen) in patients at risk who need to take NSAIDs continuously.

Pantover injections are used for:
• treating mild forms of oesophageal disease caused by reflux of acid from the stomach (with or without mild inflammation of the oesophagus) and the associated symptoms (e.g. heartburn, acid regurgitation, pain on swallowing).
• long-term management of reflux oesophagitis (inflammation of the oesophagus accompanied by the regurgitation of stomach acid) and preventing its return.
• preventing duodenal and stomach ulcers caused by non-steroidal anti-inflammatory drugs (NSAIDs, for example, ibuprofen) in patients at risk who need to take NSAIDs continuously.

Tablet

Disease

Dosage and administration

Benign gastric ulcer 40 mg daily in the morning for 4 weeks, continued for further 4 weeks if not fully healed.
Duodenal ulcer 40 mg daily in the morning for 2 weeks, continued for further 2 weeks if not fully healed.
GERD 20-40 mg daily in the morning for 4 weeks, continued for further 4 weeks if not fully healed.
NSAIDs induced peptic ulcer 20 mg daily
Acid hypersecretory conditions including Zollinger-Ellison Syndrome  Initially 80 mg once daily adjusted according to response (Elderly-maximum 40 mg daily), daily doses above 80 mg given in two divided doses
Eradication of Helicobacter pylori 40 mg twice daily by triple therapy with antibiotics
Ulcer resistant to H2 receptor antagonists  20 mg daily as a maintenance therapy, increased to 40 mg daily if symptoms return.

Injection

Duodenal ulcer and gastric ulcer 40 mg once daily for 7-10 days
Gastroesophageal reflux disease associated with a history of erosive esophagitis 40 mg once daily for 7-10 days
Prevention of rebleeding in peptic ulcer IV 80 mg, followed by 8 mg/hour infusion for 72 hours
Prophylaxis of acid aspiration 80 mg IV every 12 h for 24 h, followed by 40 mg every 12 h
Long-term management of Zollinger-Ellison Syndrome and other pathological if needed, may titrate to higher doses depending on acid output hypersecretory conditions 80 mg IV every 12 hours, may increase to 80 mg every 8 hours

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